INS and diabetes mellitus: Daily consumption of polyphenol-rich extra-virgin olive oil improved metabolic control (significant reduction in fasting plasma glucose (p = 0.023), HbA1c (p = 0.039) levels, BMI (p = 0.012), and body weight (p = 0.012)), as well as the circulating inflammatory adipokine profile, in overweight patients with diabetes that were not being treated with insulin [65].