The use of active comparators (i.e., DPP-4i, insulin, sulphonylureas), the short duration of type 2 diabetes and consequently the low risk of heart failure, the small number of events accrued, and the different baseline features of enrolled populations could potentially explain why results from observational studies were less prominent compared to CVOT [28]. The gene discussed is INS; the disease is type 2 diabetes mellitus.