In the crossed B6.Nrf2−/−lpr/lpr mice, early-stage nephritis increased, and this was associated with Th17 activation and an increase in Th17 relevant cytokines (Il17, Il17f, Il23, Il23r, and Rorγt), suggesting a role for Nrf2 prevention of Th17 differentiation and function in LN. The gene discussed is NFE2L2; the disease is nephritis.