In terms of the molecular and cellular mechanisms for its preventive action, we have previously reported that GGA induces cell death in human hepatoma-derived cells via several cellular processes, including (i) endoplasmic reticulum stress response [3], (ii) incomplete autophagic response [4], and (iii) Toll-like receptor 4 (TLR4)-mediated pyroptosis [5]. Here, TLR4 is linked to hepatocellular carcinoma.