Our data suggest that primary human macrophages from healthy volunteers exposed to serum from diabetic vs. non-diabetic AAA patients exhibited higher metabolic activity (i.e., both glycolysis and fatty acid oxidation (FAO)), based on increased extracellular acidification and the increased expression of genes/proteins involved in those metabolic pathways (i.e., Glut1, PPARs, LXRα, and CPT1a). This evidence concerns the gene NR1H3 and triple-A syndrome.