SPARC and Glucose intolerance: To highlight the similarities between ageing effects (either shown from our data or from the literature) and Sparc KO, our data, as well as the results we previously reported from the same set of Sparc KO experiment mice [11], showed that Sparc KO led to an ageing-like phenotype, including muscle loss, grip power reduction, lower oxidative phosphorylation, glucose intolerance, and reduced glucose transport into muscles.