RETN and cardiovascular disorder: Of interest, some of the agents able to reduce small dense LDL, such as exenatide and liraglutide, are also concomitantly reducing the concentrations of the pro-atherogenic adipokine resistin [77,78]; since previous studies have shown that small, dense LDL and resistin are closely linked for increased risk of cardiovascular diseases [79], we cannot exclude this pathway may represent a valuable mechanistic explanation for the cardiovascular benefit of most, but not all, antidiabetic therapies.