Reproducing our prior observations using the C57BL/6 mice [5], our current study showed that exposure of pregnant F0 dams of the OG2 transgenic mice [10] backcrossed to the C57BL/6 genetic background to a low dose of TBT caused diet-induced obesity in F3 generation males. Here, NOBOX is linked to obesity due to melanocortin 4 receptor deficiency.