GPT and Hepatic fibrosis: Among the simple fibrosis biomarkers potentially suitable as first-tier tests, the aspartate aminotransferase (AST): alanine aminotransferase (ALT) ratio, the fibrosis-4 (FIB-4), the AST-to-Platelet Ratio Index (APRI), the NAFLD fibrosis score and the BARD score have been sufficiently validated for the diagnosis of significant liver fibrosis, as well as for their prognostic value in predicting liver-related events and mortality [24,25].