In the same manner, ILK is highly expressed in the first trimester of pregnancy, where it seems to stimulate and regulate migration and invasion of cytotrophoblast lines in vivo, which is crucial for the process of placentation [20] However, previous studies have found substantial changes in the expression of ILK under pathological pregnancies such as pre-eclampsia or gestational diabetes [38,39]. The gene discussed is ILK; the disease is gestational diabetes.