APOE and myocardial infarction: Experiments on apoE-/- mice demonstrated that myocardial infarction caused by artery ligation leads to an accelerated accumulation of innate immune cells, namely, an increase in both the total number of monocytes/macrophages in the aorta and a subpopulation of pro-inflammatory monocytes with a high content of Ly-6C as well as larger atherosclerotic lesions with a more advanced morphology relative to individuals without myocardial infarction [22].