Although there is limited information on a potential role of these two proteins in schizophrenia, altered phosphorylated Sirt2 protein expression was reported in response to the antipsychotic clozapine in rat nucleus accumbens [30], whereas myelin mutant mice lacking Cldn11 expression showed changes in behavior and neurotransmitter level imbalance [31]. The gene discussed is CLDN11; the disease is schizophrenia.