Further insights on the kidney protective effects of GLP-1 receptor agonists were provided by a combined analysis of 12,637 patients with T2DM enrolled in the LEADER (Liraglutide Effect and Action in Diabetes: Evaluation of Cardiovascular Outcome Results) and SUSTAIN-6 (Trial to Evaluate Cardiovascular and Other Long-Term Outcomes With Semaglutide in Subjects With Type 2 Diabetes) trials [43]. This evidence concerns the gene GLP1R and type 2 diabetes mellitus.