SPP1 and pregnancy disorder: As a first approach in understanding impaired implantation and pregnancy disorders characteristic of women with adenomyosis, expressions of secretory and gestational endometrial biomarkers SPP1, PAEP, LIF, and 17βHSD2 were evaluated in adenomyosis sec- and gest-organoids by qRT-PCR and compared with Control sec- and gest-organoids (Figure 4A–D).