Starting from the strong correlation of ATP7B and TMEM16A expression observed in human HNSCC tumor samples isolated from 13 patients, Vyas and collaborators went on investigating transfected cells and concluded that TMEM16A protein overexpression in turn determines ATP7B mRNA levels, and thus cisplatin cell sensitivity, probably through a mechanism involving oxidative stress [145]. The gene discussed is ATP7B; the disease is head and neck squamous cell carcinoma.