According to the database of the anatomical variants of the ARVC (The ARVC Genetic Variants Database), in the last two decades more than 1400 variants of the 12 genes involved in ACM have been discovered, as follows: plakophilin (PKP2), desmoplakin (DSP), desmochollin (DSC2), desmoglein (DSG2), plakoglobin (JUP), transforming growth factor (TGFG3), transmembrane protein 43 (TMEM43), A/C lamina (LMNA), desmin (DES), titin (TTN), phospholamban (PLN), catenin alpha-3 (CTNNA3). The gene discussed is TMEM43; the disease is Arrhythmogenic right ventricular dysplasia.