In a study by Guo at al., which assessed the role of adiponectin and its receptors in vivo, the authors found that angiotensin II (Ang II)-induced hypertension led to a significant decrease in the expression of both adiponectin and its AdipoR1 and AdipoR2 receptors in perivascular adipocytes and vascular cells [38]. This evidence concerns the gene ADIPOR1 and hypertensive disorder.