TIGIT and neoplasm: Moreover, the relationship between the microbiota and the immune system has allowed endogenous pathogens to interfere in the tumour microenvironment by activating pro-tumorigenic immune responses like ETBF increase in mice models the T-Th17 that is generally associated with worse prognosis in CRC and Fusobacterium nucleatum use Fad 2 adhesine binding to the T cell immunoreceptor with immunoglobulin and immunoreceptor tyrosine-based inhibitory motif domains (TIGIT) to silence the tumour-killing capabilities of cytotoxic immune cells, among other mechanisms described [56,57].