BRAF and colorectal carcinoma: On the other hand, the V-raf murine sarcoma viral oncogene homolog B1 (BRAF) gene is mutated in 10–15% of patients with CRC, it is found in exon 15 and around 80% corresponds to the T17991 transversal mutation causing the V600E amino acid substitution, while the other 20% corresponds to a wide variable range of missense mutations all residing in the G-loop glycines in exon 11 or in exon 15 near V600 [11,12,13].