IFNG and colorectal carcinoma: The prognostic value of CMS subgroups has been extensively studied over the last few years but Galon and colleagues [35,36,37] were among the first to highlight the relevance of immunologic phenotypes in the prognosis of early-stage CRC, describing that high lymphocyte infiltration, especially of Th1 CTLs and interferon gamma (IFNγ), correlates with positive overall survival (OS) and disease-free survival (DFS), and higher levels of interleukin (IL 17) and Th17 are associated with worse outcomes, which may be linked to their ability to develop pro-metastatic immune evasive mechanisms.