Depletion of the pool of resident macrophages in the early period of MI due to their polarization into M1 macrophages, together with the replenishment of renal tissue with alien M1 macrophages, promotes the release of GM-CSF into the bloodstream, which causes the polarization of myocardial macrophages into M2 type. Here, CSF2 is linked to myocardial infarction.