PRTN3 and granulomatosis with polyangiitis: In this regard, serum IL-1, IL-32 and IL-6 [94,95,96] seem to be elevated in patients suffering from AAV and directly correlate with disease activity [97], namely skin vasculitis in patients with GPA and high levels of ANCA-PR3 [95], also displaying a direct correlation with the risk of relapse [98] among the patients treated with anti-CD20 agents.