After analyzing PRM and TNP gene nucleotide variations and sperm DNA integrity of 100 oligozoospermic infertile men, 7 nucleotide variations including two novel changes, a non-synonymous mutation in the exon-2 of PRM2 gene (c.443C > A) and a novel insertion of T (c.396_397InsT) at the 3’UTR region of TNP1, were detected [83]. The gene discussed is TNP1; the disease is Infertility.