INS and type 2 diabetes mellitus: Pharmacologically significant agents, such as biguanides, sulfonylureas, meglitinides, thiazolidinediones, alpha-glucosidase inhibitors, incretin-based therapies, dipeptidyl-peptidase IV inhibitors, insulin analogs, and bromocriptine, have been reported as potential for T2DM patients in clinical scenarios [9,12,13,14,15].