IL1B and hyperostosis: Furthermore, prior works showed that the MBL2 (SNP 49 C/T rs5030737) gene polymorphism [24]; the AG + GG and AG genotypes at TLR4-D299G [39]; Ugrp2 [40]; and the 2R, 2R, Il-1Ra and T, and T IL-1b genotypes [41] were associated with an increased risk of developing adenoid hypertrophy.