Conversely, it was also demonstrated that interaction between Bcl-2 and Noxa can be observed in vivo in RL cells (diffuse large B cell lymphoma) that constitutively overexpressed Bcl-2 and in human colorectal carcinoma cell line initiated from an adult male (HCT116) colon cancer cells that were treated with the topoisomerase I poison camptothecin, which causes upregulation of Noxa levels [139]. This evidence concerns the gene PMAIP1 and malignant colon neoplasm.