IFNA1 and systemic lupus erythematosus: Type I IFN’s functions listed here and the impaired clearance of apoptotic particles (residues) in patients with SLE promote the formation of immune complexes that are potent inducers of IFN type I. Thus, inadequate IFN production and/or inability to suppress the effects of signalling pathway activation can initiate a positive feedback loop, leading to the persistence of the autoimmune response [10,11].