The aim of this study was to investigate the role of MTHFR rs1801133, MTHFR rs1801131, MTR rs1805087, MTRR rs1801394, DNMT1 rs8101626, DNMT3B rs1569686 and DNMT3B rs2424913 gene polymorphisms as a predisposing factor for in-stent restenosis development in patients with CAD after coronary revascularization. This evidence concerns the gene MTHFR and coronary artery disorder.