Unlike aEA-VMTD that triggers life-threatening thrombotic thrombocytopenic purpura (TTP)-like syndrome [5], vEA-VMTD is “silent” and ‘transient” disorder because efficient physiologic dissolution of microthrombi takes place by ultra large usually large von Willebrand factor (ULVWF)-cleaving protease ADAMTS13 in slow venous circulation. Here, ADAMTS13 is linked to thrombotic thrombocytopenic purpura.