In recent work, we demonstrated a reduced immune cell peritumoral infiltration in patients with RDEB, with a significant reduction in CD3+, CD4+ and CD68+ in RDEB patients with cSCC compared to primary cSCC in patients without RDEB, as well as a significant reduction in CD3+, CD4+, CD8+ and CD20+ in RDEB patients with cSCC compared to non-RDEB patients with secondary cSCC (post-burns and post-radiotherapy) [5]. This evidence concerns the gene CD4 and recessive dystrophic epidermolysis bullosa.