HMGCR and atherosclerosis: As an additional design point in this study, on the basis of the inhibitory effect of HMG CoA reductase activation by Poncirus trifoliata extract [48], a component of DSHT with the same mechanism of action as AT, we expected that the addition of DSHT to AT therapy would enhance the anti-atherogenic effect in a mouse model with HFD-induced atherosclerosis.