In the investigated mouse model of asthma, a double effect of LPS and GMDP was established: multiple administration of LPS and GMDP before sensitization reduces neutrophilia and eosinophilia and the levels of IgA in BALF and IgE in blood serum, while their joint administration together with an allergen significantly increases neutrophilia, eosinophilia, as well as IgA and IgE levels. Here, IGHE is linked to asthma.