The Ang II-induced mouse AAA model is established based on the hyperlipidemia mice, such as ApoE−/− or LDLR−/− male mice, that are susceptible to AAA formation with Ang II infusion, which yields an AAA incidence of approximately 80%, while in WT C57BL/6 mice the incidence is only 25%. This evidence concerns the gene APOE and triple-A syndrome.