For CD133, a phase I study of CAR-T cells targeting CD133 in 23 patients with advanced-stage hepatocellular, pancreatic, or colorectal carcinoma revealed a manageable toxicity profile, mainly with grade ≤ 3 decreases in hemoglobin levels and/or platelet counts that recovered rapidly and spontaneously, as well as signs of efficacy, including three partial responses [174]. The gene discussed is PROM1; the disease is colorectal carcinoma.