Moreover, the effect of silencing C1GALT1 on CCA progression was demonstrated by up-regulation of growth-related genes (CCND1, CDK4, CCNE1, and c-Myc) and the ABC transporter superfamily (ABCC1, ABCC3 and ABCG2) (Figure 3F). Here, ABCC3 is linked to cholangiocarcinoma.