ACE2 and infection: Alpha (B.1.1.7): identified in September 2020, presents a 70% increase in transmissibility, consequence of key changes, specifically in the RBM (N501Y) and near the furin cleavage site (P681H), which could increase the affinity for ACE2 and have an impact on infection and transmission, respectively; [30] this could have contributed to the rapid dispersion and dominance of this variant in the world before the arrival of the Delta variant (B.1.617.2).