Figure 5d showed that the anti-B7-H3 mAb did not induce T cell proliferation and demonstrated that αB7-H3/CD3 had a stronger effect on induction of both CD8+ (left) and CD4+ (right) T cell proliferation compared to anti-CD3 mAb and mAb mix. Additionally, when we replaced U-87 MG with no tumor or Raji, αB7-H3/CD3 did not induce T cell proliferation, which indicated that this effect was associated with the expression of B7-H3 (Figure 5e). The gene discussed is CD8A; the disease is neoplasm.