SLC6A3 and cocaine abuse: Specifically, it targets and blocks the dopamine transporter (DAT) in the mesolimbic reward system, causing a rapid increase in extracellular dopamine levels and the subsequent activation of dopamine receptors, the post-synaptic D1 receptors and the pre- and post-synaptic D2 receptors, which produces reinforcing effects that lead to cocaine abuse [3,4].