Notably, these studies adopted an incomplete CD screening strategy: indeed, Khoene et al. and Nisihara et al., respectively, performed the serological screening by using anti-gliadin antibody(AGA)/anti-endomysia antibody (EmA) and EmA/anti-tissue transglutaminase IgG (tTG IgG), which are not the most sensitive serological markers for CD [17,21]. The gene discussed is TGM2; the disease is Cowden disease.