CRP and infection: CRP had also shown usefulness in the timely stratification of the risk of infection in critically ill patients (patients presenting maximum daily CRP variation >4.1 mg/dL plus a CRP level >8.7 mg/dL had an 88% risk of ICU-acquired infection [54]), in prediction of VAP in the first six days of mechanical ventilation (rate of CRP change per day, highest level and maximum amplitude of variation were all significantly associated with VAP development [55]), and in anticipation of community-acquired bloodstream infection (CRP concentrations began to increase 3.1 days before diagnosis [56]).