In another cohort of burn patients admitted to the ICU, PSP demonstrated a 3.3–5.5-fold increase for up to 72 h before the diagnosis of sepsis [50] and among those with inhalation injury and ARDS, PSP was the strongest marker to identify sepsis when compared to CRP and PCT both by its higher values and steeper increase over time [51]. This evidence concerns the gene CRP and acute respiratory distress syndrome.