CRP and Sepsis: Klein et al. [49] showed that in a cohort of burn patients admitted to the ICU without sepsis, the serum levels of PSP remained unchanged over time not only after the initial burn injury but also after secondary debridement procedures in contrast to CRP and PCT both of which significantly increased after inflammatory and/or surgical insults, suggesting that PSP might be a more robust biomarker of sepsis in this particular setting.