TNF and Sepsis: Que et al. [58] prospectively analyzed the serum value of a set of biomarkers (PSP, CRP, PCT, IL-6, IL-8, IL-10, TNF-α and IL-1 ß) in 107 patients with severe sepsis and septic shock (according to the Sepsis 2 criteria) in the first 24 h after ICU admission.