Riociguat is an oral stimulator of the soluble guanyl-cyclase (sGC stimulator) [3] approved for the treatment of adults with PAH and adults with chronic thromboembolic hypertension (CTEPH) who are inoperable or have persistent/recurrent PH after pulmonary endarterectomies (PEA) [4,5,6] but not for patients with PH due to left heart or lung disease [7,8,9]. Here, SGCB is linked to pulmonary arterial hypertension.