Receiver operating characteristic (ROC) curve analysis showed that GCK methylation could provide high discrimination between T2DM patients and healthy individuals (AUC 0.848 (95% CI 0.787–0.910)) (Figure 4), while IAPP and KCNJ11 methylation could offer lower discrimination between groups (AUC 0.727 (95% CI 0.649–0.805) and AUC 0.712 (95% CI 0.619–0.806), respectively) (Figure 4). This evidence concerns the gene KCNJ11 and type 2 diabetes mellitus.