Our observations are similar to the analysis by Mazza et al., who showed that, in the subgroup of patients with systemic inflammatory response syndrome/sepsis with Hb < 8 g/dL (mean pre-RBCT Hb 7.34 ± 0.48 g/dL), RBCT did not normalise lactate (pre-post RBCT lactate 2.02 ± 1.20 vs. 1.92 ± 0.80, p = 0.80) [16]. The gene discussed is GSTM1; the disease is systemic inflammatory response syndrome.