In patients developing AKI 2/3 within the first 48 postoperative hours, [TIMP-2]*[IGFBP7] increased significantly four hours after surgery (0.6 ± 0.69 vs. 0.37± 0.56, p = 0.03) but not 2 h after surgery (1.2 ±1.29 vs. 0.28 ± 0.56, p = n.s.). This evidence concerns the gene IGFBP7 and acute kidney injury.