Elevated anti-Pg IgG levels in RA versus controls have been confirmed in a meta-analysis [21], and a number of studies support an association between periodontitis/Pg and the autoimmune ACPA response [22,23,24,25,26,27], including a report demonstrating presence of ACPA in crevicular fluid of periodontitis patients [28]. The gene discussed is JUP; the disease is rheumatoid arthritis.