Other reasons as to why anti-Rgp antibody levels did not accurately match with the periodontal status in PAROKRANK could be that the dysbiotic bacteria in the oral biofilm, contributing to periodontitis, did not include Pg [44], or Rgp IgG levels may also have reflected past exposure to Pg, rather than current periodontal infection [45]. The gene discussed is JUP; the disease is periodontitis.