Most adverse pregnancy outcomes including GDM requiring insulin treatment, preeclampsia requiring magnesium sulfate administration, placenta previa, placental abruption, cesarean section, preterm birth, LBW, and postpartum hemorrhage were more frequently observed in women aged ≥35 years compared to those aged <35 years; moreover, the frequency of these adverse outcomes increased with an increase in maternal age. This evidence concerns the gene INS and placental abruption.