In this context, it is worth noting that brain inflammation, induced by the systemic administration of lipopolysaccharide, elicits a significant release of the proinflammatory cytokines TNF-α, IL-1β, and interleukin 6 (IL-6) to the systemic circulation and increases the expression of TNF-α, IL-1β, and IL-6 mRNAs in the prefrontal cortex, the PVN, the SFO, the amygdala, and the hippocampus. The gene discussed is TNF; the disease is brain inflammatory disease.