MAPT and early-onset autosomal dominant Alzheimer disease: It has been found that the Ang-(1-7) level is significantly reduced in the cerebral cortex and hippocampus of the senescence-accelerated mouse prone 8 (SAMP8) model of Alzheimer’s disease and that the inhibition is associated with an inverse correlation between the Ang-(1-7) level and tau hyperphosphorylation.