In addition, through in vivo investigations looking at the seizure behavior of negative control rats versus rats transfected with ASIC2a-expressing adeno-associated viruses, it was found that ASIC2a overexpression significantly accelerated the onset of the first seizure episode, reaching Racine stage IV (rearing with forelimb clonus) and increased the occurrence of status epilepticus episodes that reached Racine stage IV [18]. The gene discussed is ASIC2; the disease is status epilepticus.