Consequently, considering that adipose tissue also expresses most of the components of the RAAS, such as angiotensinogen (AGT), angiotensin converting enzymes (ACE and ACE2), and their receptors, an imbalance or alteration in the production of the aforementioned factors as consequence of obesity and/or other comorbidities may aggravate or jeopardize the health condition of the patient infected with SARS-CoV-2 [34]. The gene discussed is ACE; the disease is obesity due to melanocortin 4 receptor deficiency.