This category includes markers related to the inflammatory process and cell damage (serum levels of S100B, RANKL, ICAM-1, AGPT2, syndecan-1 HR, BDNF, TNF, interleukin-6, PLT, IGF-1, IGFBP-3), FGF-23, anemia, 25(OH)D levels, cardiovascular risk factors (PWV, CCAPI, LVEF), mean flow velocity in the cerebral arteries, or changes in regional cerebral blood (see Figure 2). This evidence concerns the gene IGFBP3 and anemia (phenotype).