PIK3CA and endometriosis: Gounaris et al. suggest that mutations, such as PTEN (Phosphatase and Tensin Homolog), ARD1A, PIK3CA- mTOR (phosphoinositide 3-kinases—mammalian target of rapamycin), and Ras-Raf-MAPK pathway activation in eutopic endometrium predispose one to the development of endometriosis tissue.