CTRPs, due to presence of a C-terminal globular domain, with sequence homology to the immune complement protein C1q are further counted among the C1q protein family [66], together with a commonly known adipokine, adiponectin, which is a well-established insulin-sensitizing hormone [67], the diminished levels of which reflect insulin resistance, which has been repeatedly demonstrated in PCOS individuals [68,69]. The gene discussed is ADIPOQ; the disease is Insulin resistance.